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Cat#: 107P138
序列（三字母）：H-Lys-Glu-Gly-Val-Val-His-Gly-Val-Ala-Thr-OH
序列（單字母）：KEGVVHGVAT
分子式：C??H??N??O??
分子量：996.12
合成方法：固相合成
存儲(chǔ)條件：-20 ± 5 °C，避光，干燥
應(yīng)用：Alzheimer′s Disease Parkinson’s Disease
描述：Aggregation of α-synuclein (α-syn) into toxic fibrils is a pathogenic hallmark of Parkinson’s disease (PD). Most early onset mutations are located between residues 46-53. The sequence of α-synuclein (45-54) was used by Cheruvara and coworkers as a template for a peptide library. The authors isolated a 10-residue peptide antagonist that potently inhibits α-synuclein aggregation and associated toxicity at 1:1 stoichiometry.