產(chǎn)品詳情
Cat#：163P01
序列（三字母）：H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH trifluoroacetate salt
序列（單字母）：SALLRSIPAPAGASRLLLLTGEIDLP
分子式：C???H???N??O??
分子量：2645.14
CAS#：867021-83-8
合成方法：Synthetic
存儲(chǔ)條件：-20 ± 5 °C
應(yīng)用：Alzheimer′s Disease
描述：Colivelin is a hybrid peptide which mediates neuroprotection against Alzheimer′s disease (AD)-relevant insults. It is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA(C8R)HNG17, a potent humanin derivative. Colivelin completely suppressed death induced by overexpressing familial AD-causative genes and amyloid β-protein (1-43) at a concentration of 100 fM. Intraperitoneally administered peptide suppressed memory impairment caused by the muscarinic acetylcholine receptor antagonist, 3-quinuclidinyl benzylate, indicating that a substantial portion of intraperitoneally administered colivelin passes through the blood brain barrier.
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